Stability and Effective Process Control for Secure Email Filtering

A fantastic tool for both commercial and personal communication is electronic mail. It has increasingly become a necessary component of our working life since it is straightforward, available, and simple to use. Spam emails have started to tarnish internet experiences and threaten the integrity of email. Due to the exponential growth of spam, both people and organisations are under a great deal of financial and other strain. In order to prevent the future of email itself from being in jeopardy, a solution to the spam problem must be discovered. There is an urgent need to solve the Email spam issue since spam volume has been rising over the last several decades. As part of this effort, many effects of spam emails on businesses and people were noted and thoroughly examined. In order to properly assess current technologies, solutions, and methods, a comprehensive literature review was conducted throughout the procedures. The goals of this work is to develop new methodologies for the implementation of new strategies for the efficient management of email spam and to construct a proof-of-concept software system for the Process controlled assessment of such strategies

Functional Analysis of the Phycomyces carRA Gene Encoding the Enzymes Phytoene Synthase and Lycopene Cyclase

Phycomyces carRA gene encodes a protein with two domains. Domain R is characterized by red carR mutants that accumulate lycopene. Domain A is characterized by white carA mutants that do not accumulate significant amounts of carotenoids. The carRA-encoded protein was identified as the lycopene cyclase and phytoene synthase enzyme by sequence homology with other proteins. However, no direct data showing the function of this protein have been reported so far. Different Mucor circinelloides mutants altered at the phytoene synthase, the lycopene cyclase or both activities were transformed with the Phycomyces carRA gene. Fully transcribed carRA mRNA molecules were detected by Northern assays in the transformants and the correct processing of the carRA messenger was verified by RT-PCR. These results showed that Phycomyces carRA gene was correctly expressed in Mucor. Carotenoids analysis in these transformants showed the presence of ß-carotene, absent in the untransformed strains, providing functional evidence that the Phycomyces carRA gene complements the M. circinelloides mutations. Co-transformation of the carRA cDNA in E. coli with different combinations of the carotenoid structural genes from Erwinia uredovora was also performed. Newly formed carotenoids were accumulated showing that the Phycomyces CarRA protein does contain lycopene cyclase and phytoene synthase activities. The heterologous expression of the carRA gene and the functional complementation of the mentioned activities are not very efficient in E. coli. However, the simultaneous presence of both carRA and carB gene products from Phycomyces increases the efficiency of these enzymes, presumably due to an interaction mechanism

Dermatomyositis associated with adenocarcinoma of the lung: A case report

The association of dermatomyositis and underlying malignancies, especially small cell and squamous cell carcinoma of the lung, has been recognized a long time ago. We report the case of a 63-year-old male chronic smoker with adenocarcinoma lung associated with dermatomyositis. The occurrence of dermatomyositis should be considered as a potential presentation of paraneoplastic syndromes and physicians encountering similar clinical situations should perform extensive diagnostic work-up to exclude underlying neoplastic lesions